Alzheimer disease (AD) is the sixth leading cause of death, presently in America. AD is the centre of preoccupation of not only the scientific community, but also of the intelligentsia. The study of various structures of the brain, their connections and the pathways involved (anatomy), their normal functioning (physiology) and how this is subverted, leading to AD (pathology and pathogenesis), is vital to understanding comprehensively the complete gamut of clinical features of the Alzheimer disease. The anatomical structures, their connections and interplay, as implicated as having a role in AD, are briefly reviewed in this article. The functional significance with AD, of each structure is highlighted.
