Desmoplastic ameloblastoma (DA) is relatively rare histologic variant of solid multicystic ameloblastoma (SMA) which is characterized by its peculiar histomorphology, that is stromal collagenization which has led to the term ‘ameloblastoma with pronounced desmoplasia’ hereby present a case of desmoplastic ameloblastoma in a 22 year female and have made an attempt to discuss the various molecular and genetic markers of amelobalstoma that could affect the treatment plan and aid for the better prognosis.
