This study aims to explain income-generating activities like occupation (formal, informal jobs) and other sociodemographic factors that potentially increase the risk of drug dependence and possible relapse. Study participants of 632 patients with a data survey form of questionnaire in 5 different drug treatment facilities were collected from July 2019 to September 2019, in 2 areas of NCR-Manila, Southwestern Visayas, and Davao CityMindanao, Philippines. There were 42.55% of nicotine dependence, 41.88% alcohol use, 39.53% methamphetamine, and 52.24% cannabis dependence in a 30-day income generation, found to increase drug dependence significantly. A multiple logistic regression analysis was used to utilize the odds ratio of income generation and occupation (formal, informal jobs)