Bronchoscopy guided biopsies can help to diagnose pulmonary lesions if endobronchial mass is seen. However a deep seated lung lesions is difficult to get yield if no obvious mass lesions seen during bronchoscopy. A Virtual bronchoscopic navigation (VBN) is a promising navigational bronchoscopy method that guides us to the lung lesions with the virtual images for better yield. The primary purpose of this case report is to present the valuable diagnosing utility of virtual bronchoscopic navigation for deep seated peribronchial peripheral lung lesions